Effect of Substituents on the Biological Activity of Isatin Hybrids – A SAR Study

Isatin (2,3-dioxindole) is a benzopyrrole derivative that belongs to large class of heterocyclic chemicals. derivatives are essential synthetic substrates can be utilized as starting materials build wide range heterocycles with diverse applications in pharmaceutical sciences. therefore have recently gained lot attention. This review emphasizes on the Schiff base from isatin, isatin quinoline/flouroquinone, -thiazole, isatin–azole hybrids, all possessing potential biological activity. The structure–activity relationships these leads also discussed.